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upgrading computer with FPGA interface

We are going to be upgrading a computer that is about 10 years old and uses a Com port to interface to an FPGA, running Lab View.  The new computer only has USB, just wondering if a cable converter (with driver) work ok with the new computer runing the old executable?  Also wondering if anyone knows if upgrading from windows ME to windows XP will cause any problems?  The Lab View also interfaces with an NI PCI-DIO32 card.

Thanks Paul.

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