If I am reading your question properly, you are trying to read 4 channels of analog data through a serial port on your PC. Correct?
Doing low-speed analog acquisition through a serial device is a very easy thing to do. There are a number of companies that make small external boxes that read as many as four analog channels. Two companies that come to mind right off the top of my head are Opto22 in California and DGH in New Hampshire (both here in the US).
In terms of interface circuitry, assuming that the devices have voltage outputs, the interface circuitry should be as easy as hooking up the wires.
What sensors specifically are you using, and what do their outputs look like?
Mike...