Hello,
If you can post the following I'll take a closer look:
1. The language you are using (C#, VB ?)
2. The import or using statement you are using appropriate for the language.
3. The open, write, read, and close statements
It sounds like you are using NI-488.2 calls; have you tried NI-VISA? You should be able to get and use the default resource manager and then open a GPIBSession to communicate over your GPIB.
Either should work (NI-488.2 or NI-VISA calls); repost if you are still having problems!
Best Regards,
JLS