Within the Edit Panel dialog box (for your main panel) in the UIR editor, take a look at the options when you click on "Other Attributes". In particular, disabling "Scale contents on resize", and setting resolution adjustment to 0%, may help you avoid needing to tinker with the display aspect ratio settings.
However, that won't help getting the flexibility of filling two different aspect ratio screens. For that I think you'd need to programmatically create your panel on the fly with the size and position of controls calculated based on the size of the available the screen.
Hope this helps,
Ian