It depends on the type of cable you have and the type of instrument your shutter is. The PC is a DTE port, and if the instrument is also DTE then you will need the null-modem adapter and a straight-through cable, or just a null-modem cable. If the device is a DCE device, then all you need is a straight through cable.
If the current configuration does not work, then the chances are you don't need the null-modem adapter. Instead use a gender-bender that doesn't swap TX and RX.