In past versions, the most compact solution (least bytes) for distributing an application to a virgin (non LV-installed) machine was to let the application builder install LVRT.DLL together with serpdrv and of course the .exe in the same directory.
In my humble opinion, a person that installs software should do the least steps possible.
The advised method of installing the LV runtime, the VISA stuff and finally the application looks strange to me.
The method I described is only possible if you use the old serial vi's.
Note: I have not used the most recent application builder so the most compact method could be different.
Patrick