Hello wholland,
What are you setting for the Min and Max range? Make sure that you are setting the range of your signal after the custom polynomial scale is applied. For example, if you knew that your original signal was between 0-5 V and you applied a scale that multiplied all values by 2, your new range would be 0-10 [custom units]. In this case, you would set the Min to 0 and the Max to 10, even though your highest voltage is 5V. The Min and Max correspond to the custom units, not the original voltage.
Thanks,
Justin M.
National Instruments