Looking at your manual, section 19.11 page 128 and Table 112 show the format and commands to send out the serial port. I think you could use VISA vi's to talk to the unit. One problem that I see is that it requires a checksum in the command. I did not see any mention as to what type of checksum calculation to use.
Looking at Section 20 Table 125, if those are the programming instructions that need to be converted and sent out the serial port, I think you are in for a ton of work to implement this vi.
Maybe you could use the Flash program and monitor the serial port communications to capture the data stream as it is transmitted.
I'll attach a vi that I used to talk to a scope with the serial port. Look at the structure of initializing the serial port, sending commands, and closing the serial port.