What kind of drop-down control are you using? Is it just the VISA Resource Name control or something else? Are you maybe getting the com port names from the visaconf.ini file? You should be aware that Com1, Com2, etc, are aliases and that with just NI-VISA installed, the names are ASRL1::INSTR, ASRL2::INSTR. Could you perhaps post your VI for someone to look at?