Your suggestion got me to a solution - I used the following to get the comment in C:
TS_PropertyObjectFileAsPropertyObject (panelRec->seqFile->seqFileH, &errorInfo, &fileProperty);
TS_PropertyGetPropertyObject(fileProperty, &errorInfo, "Data", 0, &dataProperty);
Then all I had to do was:
TS_PropertyGetProperty (dataProperty, &errorInfo, TS_PropertyComment, CAVT_CSTRING, &psCommentStr);
And this allows me to get the sequence file comments.
Thanks!