What OS are you running on the PXI-8186? If it is Windows, then I would expect a Windows driver that came with your USB-to-COM port device to work. If you are using an RT-OS, it would surprise me if it worked ... However, doesn't the 8186 have a COM port? I'm pretty sure I wired a DB9 cable into mine ... Yes, it's in the upper right corner of the Controller.