Hello,
The remote connection you use to talk to your PXI chassis should not affect your VISA programming. More specifically, a PXI serial interface should show up as a COM port, and you can use VISA to communicate with it via its resource name (usually an alias such as COM2). How you use VISA will depend on your choice for development platform. For example, in LabVIEW you could use VISA Configure Serial Port.vi along with VISA Write, VISA Read, and VISA Close functions. You may also use a property node for more advanced features. In any event, if you repost with your choice of development environment, I can likely point you to an example you can use to get more comfortable.
Regards,
JLS