Thanks for the fast reply. So it sounds like ref mem will work for my application, I just need to figure out how to connect the PC and ref mem module (for my application, VeriStand must run on a PC that connects to the PXI systems). I'm thinking I can connect them as shown in the 2nd diagram in my original post, or simplify it by combining the two PXI systems like:
So in this case, the two targets (PC and PXIe-8880) share data through a single ref mem module, configured as hardware for both targets in VeriStand. The PXIe-8880 can access the ref mem module since it's in the same chassis, and the desktop can access the ref mem module through the MXI connection.
From searching online I haven't been able to 100% convince myself this will work as expected, and I'd like to know that it works before I commit to buying hardware. Any insight you (or anyone else) might have would be greatly appreciated.