If you setup a DNS alias for your SystemLink server you will need to add the alias to the TLS certificate that is auto generated for the Skyline message bus.
To add the DNS alias to the TLS certificate create a file at C:\ProgramData\National Instruments\Skyline\Certificates\tls_configuration.json with the following content.
{
"SubjectAltNames": [
"alais.domain.com",
"public.dns.name",
"1.2.3.4"
]
}