Unfortunately, it is likely an issue due to incompatibility. SignalExpress 2015 is not supported by Windows 10:
http://www.ni.com/pdf/manuals/374767b.html
For new applications, I would highly recommend looking into DAQExpress, our spiritual successor to SignalExpress:
http://www.ni.com/en-us/shop/daqexpress.html
CH
Applications Engineering
National Instruments
http://www.ni.com/en-us/support.html