Hello,
Sometimes you may get the "Interface not Supported" depending on what you are doing. Ex.: If you try to display a form and you use Form1.Show without the vbModal keyword, you get an error. It needs to be modal in order to be properly displayed. You may also check under Project Properties what Version Compatibility you are using. By default it should be Project Compatibility, but Binary should also work fine.
What are you doing in your code? Are you using any 3rd party ocx in your VB Project? Can you give some more details?
Roberto Piacentini
National Instruments
Applications Engineer
www.ni.com/support