My PCI-MIO-16XE-50 can't read any analog inputs (always sees the most negative possible voltage) and can't write any analog outputs (outputs always 0). It was working fine on Friday, and I don't know what happened over the weekend to make it fail--the card was in a computer, but wasn't plugged in to any other hardware. I'm using the measurement and automation explorer to check whether it works, so it's not a software issue. The card is only a couple of months old--possibly still in warranty.