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I personally have not tried, but I see no reason why it wouldn't. Give it a try and post your results. You can even create a tutorial if you want like "How to install NI-488.2 on Fedora 10" (or whatever NI driver you want to install). I suspect on Fedora 10 your tutorial would be something simple like "install NI-KAL 1.9 then install NI-488.2 2.5.1b1", but I'm sure it would help other users who are not using officially supported distributions.