At first thanks for your quick reply Jochen. But in the specification their are also several "Input Common Mode Range" values in respect to gain released.
+-12V for gain >=0 differential mode (with warnings, that overvoltage can damage the device)
+-42.4 V for Gain <0 differential mode (with warnings, that overvoltage can damage the device)
The Problem is, that I use the PCI 4461 card in a test sequencer and that I use different modes in reference to the corresponding measurement. So if I interprete your answer right, the pci 4461 card is after every cleared measurement task in differential mode. At which gain? Sorry but I read the specification very precise and havent found a characterisation.
Thanks one more for your help
With best regards
MOD