First of all I know this may sound crazy, but I do have a specific use case (2 actually) and I think it generalizes well.
Use Case
Caraya uses a Quickdrop shortcut ctl+u to run all unit tests in your project. I have a quickdrop shortcut that I use to run VI Analyzer on just the files that have changed in Git.
Both of these shortcuts are incredibly useful. However it requires having a VI open. There are often times when I just have a project open and want to use one of these shortcuts. For example when I first open a project, I often want to run the tests first thing. I realize you can add these type of things to the tools menu, but then I have to memorize 2 different ways of doing something depending on context. It would be much easier to use the QD shortcut here.
I realize that QD is typically used for dropping objects (on the bd and fp) and that doesn't really make sense from the project. But these shortcuts (and I'm sure there are others) don't rely on that functionality. Also you could adapt QD to act on highlighted project items or allow you to "drop" a new VI or class or library or something.
I mentioned it to Darren and he mentioned it would require the C code changes to allow the project window to capture the ctl + space event. The project window already does handle some ctl key events. Apparently ctl + space seems to be unhandled. I'm sure there is probably more to this idea than simply that, but I feel like it is worth exploring.