I'm in process of porting a commercial application that samples at 64, 128, 256,...,65536 Hz. In non-rigourous tests, my 4474 appears to work well and the anti-aliasing filters appear to work properly. I'll look at this more closely and report back. In the E series version of this application for cases where ther is a minimal hardware anti-aliasing filter, the application samples either at 131072 Hz and then successively applies a .4 sampling rate FIR anti-aliasing filter and then decimates so there would be no problem for me to sample higher on the 4474 and do the same process.