It is not possible to use the NI-DMM soft front panel in simulation mode. It is, however, possible to write your own program (or use one of the provided examples) in simulation mode. The way to enable simulation is to use niDMM_InitWithOptions with an option string containing "simulate=1". You can also select which National Instruments DMM will be simulated by adding a DriverSetup clause to the option string. The format of DriverSetup is "DriverSetup=Model:AAA;Bus:BBB" where AAA is either 4050 or 4060 and BBB is PCMCIA for the NI 4050 and PCI or PXI for the NI 4060.