When you call DIG_Block_Out, NI-DAQ first downloads your data into the 6534 memory. Only after the download is done (which should happen at about 80 MB/s) it starts outputting data and DIG_Block_Out returns. So it is safe for you to reuse your PC memory buffer as soon as DIG_Block_Out returns.
This is assuming your entire buffer fits in memory. If it doesn't, NI-DAQ will download all the data that fits and start the transfer, and as more 6534 memory becomes available the DMA channel will fill it up.
The 6534 has a 16 sample FIFO and an additional 32 MB of memory for each handshaking group. So for 32-bit transfers you can fit 8 MSamples, for 16-bit transfers you can fit 16 MSamples (per group), and for 8-bit transfers you can fit 32 MSamples (per group) in the 6534
memory.