I don't have LabVIEW installed, only Multisim and Ultiboard. Do I need to pay attention to the 1.3GB of LabVIEW, NI-VISA and NI Sytem config updates I get noticed for?
Multisim uses the LabVIEW runtime engine so my guess is that the update message is for that. It is good to keep it up to date. I would suggest that you do the update.