Hi,
If you have less than 8 signals, you should use Differential mode. This mode does not care about grounding. The only thing that you may want to do is to connect a 100 kOhm resistor between (-)terminal of your AI channel and GND, so that the signal is biased.
If you are going to need more than 8 channels, then Single Ended is the way to go for your connections.
- Referenced> use it if your sensor is connected to ground and the ground is the same as the ground for your PC
- Non Referenced> use it if your sensor is connected to a ground different from the ground of your PC or if it is not grounded.
Cheers,
AlessioD