I'm not sure what you mean because in your first sentence you say you do know how to read a file into an array and in the second sentence you ask how to read a file and put it into an array. If you file is of the format:
50,41
52,42
Then Read From Spreadsheet will create a 2D array with 50 in row 0, column 0, 41 in row 0, column 1, 52 in row 1, column 0, 42 in row 1, column 1.
If your data is of the format:
50,41,52,42
Then you can use Read From Spreadsheet, take the 1D array output and use Reshape Array to create a 2D array like in the attachment.