Ed,
Yes, that's correct. Before answering your question, just to make sure, I conducted the following test:
1. Power down my instrument
2. Open VISA Interactive Control
3. Open a VISA Session to GPIB0::6::INSTR
4. Power up my instrument
5. Visa write/Visa read from instrument.
With 488.2 v2.1 and VISA 3.1, this works perfectly. Incidentally, you can always open a VISA session to a nonexistent GPIB resource, but the read/write will fail with a "No Listeners" error if the instrument is not on the bus. If you do get the GPIB calls to fail again, get the error number to see if this is the error you are seeing or if something else is going on.
Hope this helps.
Scott B.
Applications Engineer
National Instruments