Yes you can. There are several GPIB options. PCI, USB, Ethernet, PCMCIA, ISA. You can go to NI's main web page and check prices and spec's. Serial and parallel refer to how data is transmitted. Serial transmission sends data one bit at a time over a single line. Data is received in the same manner. Most often over a separate dedicated line. There may be additional lines for handshaking (when to send, when to receive, etc.). Examples of serial data transmission are the RS-232 ports (DB9 or DB25) on a pc though these are less common these days. In these forums, when you see reference to the serial port, it typically refers to the RS232. These are low speed (300 bits/sec to 115kbits/sec). These connect to modems and some instruments. USB or Universal Serial Bus is a high speed serial. They're the little retangular connectors on newer pc's. These connect to mice, keyboards, cameras, and more and more instruments have these connections. Ethernet is another example of serial data transmission. Parallel means several data bits are transmitted simultaneously. Data widths may be 8, 16, 32, etc bits wide. The printer port on your pc is a parallel port. In these forums, when you see reference to the parallel port, it usually means the printer port. GPIB is another parallel data scheme. The PCI and/or ISA slots in a pc use parallel data.