Unless you're using all IVI drivers, there is no built in simulation mode. As long as you make calls to VISA that expect a GPIB board, you'll get errors. Even if you had a gpib board, if you write your code correctly, you would also get errors when the board doesn't find an instrument to write to or read from. The only solution is for you to write your own simulation code. Encapsultate your write/read functions with case statements that skip the driver calls and return simulated data.