If you are using NI-488 functions to communicate with VXI modules, that is just going to cause you tremendous headaches. Please use the VISA API for this. There's nothing wrong with NI-488, it just wasn't designed for VXI instruments.
VISA is designed exactly for stuff like this. It abstracts away the fact that there is a GPIB cable in the middle and lets you talk to your VXI instruments like you would talk to any other VXI instruments with any other VXI controller.
If you have had prior experience with the GPIB-VXI command set, I recommend you read Chapter 9 of the NI-VISA user manual. It gives you a good comparison between the NI-488, NI-VXI, and NI-VISA APIs. It should also help you transition more smoothly to using VISA.
Dan Mondrik
Senior S
oftware Engineer, NI-VISA
National Instruments